Think Tank is a unique formulation of seven research-backed nootropic ingredients.  Based on mechanistic rationale, we designed Think Tank to target multiple pathways* for comprehensive cognitive enhancement. While each ingredient has their own clinical validation, Think Tank's patent-pending formulation was designed to amplify nootropic benefits through complementary mechanisms while minimizing unwanted side effects.  Early user feedback is consistent with this, and Think Tank is being further tested in double-blinded, placebo controlled human studies at a prominent university in the UK - results to be published regardless of outcome.

*Think Tank is designed to enhance cognitive performance through five complementary pathways: cellular energy (creatine monohydrate), neurotransmitter synthesis (L-tyrosine, citicoline), cell membrane integrity (phosphatidylserine), stress resilience (rhodiola rosea root extract), receptor modulation (L-theanine), and cofactor support (magnesium gluconate). Unlike single-ingredient products, our multi-pathway approach supports the multifaceted, complex nature of cognitive function.

✓ "Novel, patent-pending formulation" 

✓ "Each ingredient is backed by human cognitive research studies"

✓ "Unique formulation designed around complementary mechanisms of action" 

✓ "Currently undergoing independent clinical validation of the synergistic benefits"

Ingredients and Sources

Creatine Monohydrate

  • Rae C, Digney AL, McEwan SR, Bates TC. Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial. Proc Biol Sci. 2003 Oct 22;270(1529):2147-50. PMID: 14561278 https://pubmed.ncbi.nlm.nih.gov/14561278/
  • Avgerinos KI, Spyrou N, Bougioukas KI, Kapogiannis D. Effects of creatine supplementation on cognitive function of healthy individuals: A systematic review of randomized controlled trials. Exp Gerontol. 2018 Jul 15;108:166-173. PMID: 29704637 https://pubmed.ncbi.nlm.nih.gov/29704637/
  • McMorris T, Harris RC, Swain J, Corbett J, Collard K, Dyson RJ, Dye L, Hodgson C, Draper N. Effect of creatine supplementation and sleep deprivation, with mild exercise, on cognitive and psychomotor performance, mood state, and plasma concentrations of catecholamines and cortisol. Psychopharmacology (Berl). 2006 Mar;185(1):93-103. doi: 10.1007/s00213-005-0269-z. Epub 2006 Jan 17. PMID: 16416332. https://pubmed.ncbi.nlm.nih.gov/16416332/

Magnesium

Supports attention and executive functioning; helps reduce fatigue and feelings of stress and anxiety which can impair cognitive functions.

  • Tardy AL, Pouteau E, Marquer D, Yilmaz C, Scholey A. Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence. Nutrients. 2020 Jan 16;12(1):228. PMID: 31963141 https://pubmed.ncbi.nlm.nih.gov/31963141
  • Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review. Nutrients. 2017 May 26;9(5):429. PMID: 28445426 https://pubmed.ncbi.nlm.nih.gov/28445426/
  • Zhu X, Borenstein AR, Zheng Y, Zhang W, Seidner DL, Ness R, Murff HJ, Li B, Shrubsole MJ, Yu C, Hou L, Dai Q. Ca:Mg Ratio, APOE Cytosine Modifications, and Cognitive Function: Results from a Randomized Trial. J Alzheimers Dis. 2020;75(1):85-98. PMID: 32280092 https://pubmed.ncbi.nlm.nih.gov/32280092/

L-Tyrosine

Improves working memory, cognitive flexibility, and information processing and counteracts cognitive decline under stress.

  • Jongkees BJ, Hommel B, Kühn S, Colzato LS. Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands—A review. J Psychiatr Res. 2015 Nov;70:50-7. PMID: 26424423 https://pubmed.ncbi.nlm.nih.gov/26424423/
  • Deijen et al., 1999Deijen JB, Wientjes CJ, Vullinghs HF, Cloin PA, Langefeld JJ. Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. Brain Res Bull. 1999 Jan 15;48(2):203-9. PMID: 10230711 https://pubmed.ncbi.nlm.nih.gov/10230711/

Phosphatidylserine

Supports memory consolidation, attention, and concentration and shortens delays in memory recall.

  • Glade MJ, Smith K. Phosphatidylserine and the human brain. Nutrition. 2015 Jun;31(6):781-6. PMID: 25933483 https://pubmed.ncbi.nlm.nih.gov/25933483/
  • Kato-Kataoka A, Sakai M, Ebina R, et al. Soybean-Derived Phosphatidylserine Improves Memory Function of the Elderly Japanese Subjects with Memory Complaints. J Clin Biochem Nutr. 2010 Nov;47(3):246-55. PMID: 21103034 https://pubmed.ncbi.nlm.nih.gov/21103034/
  • Hirayama S, Terasawa K, Rabeler R, Hirayama T, Inoue T, Tatsumi Y, Purpura M, Jäger R. The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial. J Hum Nutr Diet. 2014 Apr;27 Suppl 2:284-91. doi: 10.1111/jhn.12090. Epub 2013 Mar 17. PMID: 23495677.

L-Theanine

Improves verbal fluency, executive function and attention, working memory; supports mood / feelings of calm and reduces feelings of stress.

  • Hidese S, Ogawa S, Ota M, et al. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019 Oct 3;11(10):2362. PMID: 31623400 https://pubmed.ncbi.nlm.nih.gov/31623400/
  • Baba Y, Inagaki S, Nakagawa S, et al. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study. J Med Food. 2021 Apr;24(4):333-341. PMID: 33751906 https://pubmed.ncbi.nlm.nih.gov/33751906/
  • Dassanayake TL, Kahathuduwa CN, Weerasinghe VS. L-theanine improves neurophysiological measures of attention in a dose-dependent manner: a double-blind, placebo-controlled, crossover study. Nutr Neurosci. 2022 Apr;25(4):698-708. doi: 10.1080/1028415X.2020.1804098. Epub 2020 Aug 11. PMID: 32777998. https://pubmed.ncbi.nlm.nih.gov/32777998/

Citicoline Sodium

Improves multiple dimensions of memory, improves attention.

  • Nakazaki E, Mah E, Sanoshy K, Citrolo D, Watanabe F. Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Nutr. 2021 Aug 7;151(8):2153-2160. PMID: 33978188 https://pubmed.ncbi.nlm.nih.gov/33978188/
  • McGlade E, Locatelli A, Hardy J, et al. Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women. Food Nutr Sci. 2012;3(6):769-773. Link: https://www.scirp.org/html/8-2700397_19921.htm

Rhodiola Rosea

Reduces mental fatigue and improves attention.

  • Olsson EM, von Schéele B, Panossian AG. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med. 2009 Feb;75(2):105-12. PMID: 19016404 https://pubmed.ncbi.nlm.nih.gov/19016404/
  • Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine. 2000 Apr;7(2):85-9. PMID: 10839209 https://pubmed.ncbi.nlm.nih.gov/10839209/
  • Koop T, Dienel A, Heldmann M, Münte TF. Effects of a Rhodiola rosea extract on mental resource allocation and attention: An event-related potential dual task study. Phytother Res. 2020 Dec;34(12):3287-3297. doi: 10.1002/ptr.6778. Epub 2020 Jun 27. PMID: 32592534. https://pubmed.ncbi.nlm.nih.gov/32592534/